Increased sensitivity of the renal vasculature to adenosine in streptozotocin-induced diabetes mellitus rats

Détails

ID Serval
serval:BIB_0B0EB3F66875
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Increased sensitivity of the renal vasculature to adenosine in streptozotocin-induced diabetes mellitus rats
Périodique
American Journal of Physiology
Auteur(s)
Pflueger  A. C., Schenk  F., Osswald  H.
ISSN
0002-9513 (Print)
Statut éditorial
Publié
Date de publication
10/1995
Volume
269
Numéro
4 Pt 2
Pages
F529-35
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Adenosine (ADO) has been implicated as a pathophysiological factor in contrast media (CM)-induced acute renal failure, which has been encountered more often in patients with diabetes and impaired renal function. Therefore, we studied the renal vascular response to exogenous and endogenous ADO in streptozotocin-induced diabetic rats. We found that exogenous ADO (0.01-100 nmol), injected into the abdominal aorta, decreased renal blood flow (RBF) in a dose-dependent manner. The dose-response curve was shifted to the left by factor 30 in diabetic, compared with nondiabetic rats rats. Renal vascular response to endogenous ADO, assessed by postocclusive reduction of RBF after a 30-s renal artery occlusion, was significantly enhanced (P < 0.001) in diabetic rats (75.6 +/- 3.9%) compared with nondiabetic rats (36.5 +/- 2%). ADO A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine attenuated exogenous and endogenous ADO-induced renal vasoconstriction in both groups. We conclude that the ADO A1-receptor signal-transduction chain is altered in diabetic animals and that the enhanced vasoconstrictive action of ADO could be involved in the kidney pathophysiology of diabetes mellitus.
Mots-clé
Adenosine/*pharmacology/physiology Animals Diabetes Mellitus, Experimental/*physiopathology Dose-Response Relationship, Drug Male Rats Rats, Sprague-Dawley Receptors, Purinergic P1/antagonists & inhibitors Reference Values Renal Circulation/*drug effects/physiology Time Factors Vehicles Xanthines/pharmacology
Pubmed
Web of science
Création de la notice
24/01/2008 14:28
Dernière modification de la notice
03/03/2018 13:35
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