Surfactant protein-D and exposure to bioaerosols in wastewater and garbage workers.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_0B0205975C89
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Surfactant protein-D and exposure to bioaerosols in wastewater and garbage workers.
Journal
International Archives of Occupational and Environmental Health
Author(s)
Daneshzadeh Tabrizi R., Bernard A., Thommen A.M., De Winter F., Oppliger Anne, Hilfiker S., Tschopp A., Hotz P.
ISSN
1432-1246 (Electronic)
ISSN-L
0340-0131
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
83
Number
8
Pages
879-886
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
PURPOSE: Bioaerosols and their constituents, such as endotoxins, are capable of causing an inflammatory reaction at the level of the lung-blood barrier, which becomes more permeable. Thus, it was hypothesized that occupational exposure to bioaerosols can increase leakage of surfactant protein-D (SP-D), a lung-specific protein, into the bloodstream.
METHODS: SP-D was determined by ELISA in 316 wastewater workers, 67 garbage collectors, and 395 control subjects. Exposure was assessed with four interview-based indicators and by preliminary endotoxin measurements using the Limulus amoebocyte lysate assay. Influence of exposure on serum SP-D was assessed by multiple linear regression considering smoking, glomerular function, lung diseases, obesity, and other confounders.
RESULTS: Overall, mean exposure levels to endotoxins were below 100 EU/m(3). However, special tasks of wastewater workers caused higher endotoxin exposure. SP-D concentration was slightly increased in this occupational group and associated with the occurrence of splashes and contact to raw sewage. No effect was found in garbage collectors. Smoking increased serum SP-D. No clinically relevant correlation between spirometry results and SP-D concentrations appeared.
CONCLUSIONS: These results support the hypothesis that inhalation of bioaerosols, even at low concentrations, has a subclinical effect on the lung-blood barrier, the permeability of which increases without associated spirometric changes.
Keywords
Adult, Aerosols/adverse effects, Aerosols/analysis, Case-Control Studies, Dust/analysis, Endotoxins/adverse effects, Endotoxins/analysis, Environmental Monitoring/methods, Enzyme-Linked Immunosorbent Assay, Epidemiological Monitoring, Female, Garbage, Humans, Interviews as Topic, Linear Models, Male, Middle Aged, Occupational Exposure/adverse effects, Occupational Exposure/analysis, Occupations/classification, Occupations/statistics & numerical data, Pulmonary Surfactant-Associated Protein D/blood, Risk Assessment, Risk Factors, Sewage/adverse effects, Sewage/analysis, Smoking/adverse effects, Smoking/epidemiology, Switzerland/epidemiology, Waste Disposal, Fluid, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
04/01/2011 9:57
Last modification date
20/08/2019 12:32
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