Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion.

Détails

ID Serval
serval:BIB_0AD97B84FD64
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion.
Périodique
Nature Communications
Auteur(s)
Alpadi K., Kulkarni A., Namjoshi S., Srinivasan S., Sippel K.H., Ayscough K., Zieger M., Schmidt A., Mayer A., Evangelista M., Quiocho F.A., Peters C.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
2013
Volume
4
Pages
1704
Langue
anglais
Résumé
The fundamental processes of membrane fission and fusion determine size and copy numbers of intracellular organelles. Although SNARE proteins and tethering complexes mediate intracellular membrane fusion, fission requires the presence of dynamin or dynamin-related proteins. Here we study these reactions in native yeast vacuoles and find that the yeast dynamin homologue Vps1 is not only an essential part of the fission machinery, but also controls membrane fusion by generating an active Qa SNARE-tethering complex pool, which is essential for trans-SNARE formation. Our findings provide new insight into the role of dynamins in membrane fusion by directly acting on SNARE proteins.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/07/2013 8:11
Dernière modification de la notice
20/08/2019 12:32
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