The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.

Details

Serval ID
serval:BIB_0ABE8E4DE05D
Type
Article: article from journal or magazin.
Collection
Publications
Title
The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.
Journal
Journal of Virology
Author(s)
Ozmen L., Aguet M., Trinchieri G., Garotta G.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
1995
Volume
69
Number
12
Pages
8147-8150
Language
english
Abstract
The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.
Keywords
Animals, Antibodies, Monoclonal/pharmacology, Antiviral Agents/immunology, Antiviral Agents/therapeutic use, Cardiovirus Infections/immunology, Cardiovirus Infections/therapy, Dose-Response Relationship, Drug, Encephalomyocarditis virus, Humans, Interferon Type I, Recombinant/immunology, Interferon Type I, Recombinant/pharmacology, Interferon-gamma, Recombinant/immunology, Interferon-gamma, Recombinant/pharmacology, Interleukin-12/immunology, Interleukin-12/therapeutic use, Lymphocytes/immunology, Mice, Mice, Inbred C57BL, Neutralization Tests, Spleen/immunology, Time Factors
Pubmed
Web of science
Create date
28/01/2008 11:37
Last modification date
20/08/2019 12:32
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