Article: article from journal or magazin.
The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.
Journal of Virology
The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.
Animals, Antibodies, Monoclonal/pharmacology, Antiviral Agents/immunology, Antiviral Agents/therapeutic use, Cardiovirus Infections/immunology, Cardiovirus Infections/therapy, Dose-Response Relationship, Drug, Encephalomyocarditis virus, Humans, Interferon Type I, Recombinant/immunology, Interferon Type I, Recombinant/pharmacology, Interferon-gamma, Recombinant/immunology, Interferon-gamma, Recombinant/pharmacology, Interleukin-12/immunology, Interleukin-12/therapeutic use, Lymphocytes/immunology, Mice, Mice, Inbred C57BL, Neutralization Tests, Spleen/immunology, Time Factors
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