Predictors of temporary and permanent work disability in patients with inflammatory bowel disease: results of the swiss inflammatory bowel disease cohort study.
Details
Serval ID
serval:BIB_0ABE8C0D1D90
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predictors of temporary and permanent work disability in patients with inflammatory bowel disease: results of the swiss inflammatory bowel disease cohort study.
Journal
Inflammatory Bowel Diseases
Working group(s)
Swiss IBD Cohort Study Group
Contributor(s)
Aepli P., Ballabeni P., Bareiss D., Bauerfeind P., Beglinger C., Begré S., Bengoa J., Binek J., Boller D., Braegger C., Brun P., Bühr P., Burnand B., Camara R., Cremer M., Criblez D., de Saussure P., Degen L., Delarive J., Dörig C., Dorta G., Ehmann T., Engelmann M., El Wafa A., Felley C., Frei A., Frei P., Frei R., Fried M., Friedt M., Froehlich F., Frühauf H., Gallot-Lavallée S., Gerlach T., Geyer M., Giezendanner S., Girardin M., Goetze O., Guyot J., Haack H., Halama M., Hediger S., Heer P., Helbling B., Hellstern M., Hengstler P., Heyland K., Hirschi C., Hruz P., Janiak P., Jost C., Juillerat P., Brondolo VK., Knoblauch C., Krieger C., Kubli M., Kullak-Ublick GA., Maerten P., Maillard M., Manz M., Marbet U., Marsteller I., Meier R., Meyenberger C., Michetti P., Mottet C., Müller C., Müller P., Müllhaupt B., Nichita C., Nicolet T., Nüesch H., Nydegger A., Ollyo JB., Oneta C., Pache I., Piccoli F., Pilz J., Pittet V., Reichlin B., Rentsch R., Rey JP., Rihs S., Rogler D., Rogler G., Rossi L., Sagmeister M., Sauter B., Sawatzki£££Mikaël£££ M. , Schaub N., Schaub N., Schibli S., Schlauri H., Schoepfer A., Seibold F., Semela D., Sidler M., Spalinger J., Stadler P., Staub P., Steuerwald M., Straumann A., Straumann-Funk B., Sulz M., Schäppi M., Thorens£££Joël£££ J. , Tutuian R., Vader JP., Van der Weg B., Vannini S., Vavricka S., Viani F., Vögtlin J., Vouillamoz D., Von Känel R., Wachter G., Wermuth J., Wiesel P., Wildi S., Borovicka J., Leung-Ki EL., Schnegg JF.
ISSN
1536-4844 (Electronic)
ISSN-L
1078-0998
Publication state
Published
Issued date
2013
Volume
19
Number
4
Pages
847-855
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
BACKGROUND: Inflammatory bowel disease can decrease the quality of life and induce work disability. We sought to (1) identify and quantify the predictors of disease-specific work disability in patients with inflammatory bowel disease and (2) assess the suitability of using cross-sectional data to predict future outcomes, using the Swiss Inflammatory Bowel Disease Cohort Study data.
METHODS: A total of 1187 patients were enrolled and followed up for an average of 13 months. Predictors included patient and disease characteristics and drug utilization. Potential predictors were identified through an expert panel and published literature. We estimated adjusted effect estimates with 95% confidence intervals using logistic and zero-inflated Poisson regression.
RESULTS: Overall, 699 (58.9%) experienced Crohn's disease and 488 (41.1%) had ulcerative colitis. Most important predictors for temporary work disability in patients with Crohn's disease included gender, disease duration, disease activity, C-reactive protein level, smoking, depressive symptoms, fistulas, extraintestinal manifestations, and the use of immunosuppressants/steroids. Temporary work disability in patients with ulcerative colitis was associated with age, disease duration, disease activity, and the use of steroids/antibiotics. In all patients, disease activity emerged as the only predictor of permanent work disability. Comparing data at enrollment versus follow-up yielded substantial differences regarding disability and predictors, with follow-up data showing greater predictor effects.
CONCLUSIONS: We identified predictors of work disability in patients with Crohn's disease and ulcerative colitis. Our findings can help in forecasting these disease courses and guide the choice of appropriate measures to prevent adverse outcomes. Comparing cross-sectional and longitudinal data showed that the conduction of cohort studies is inevitable for the examination of disability.
METHODS: A total of 1187 patients were enrolled and followed up for an average of 13 months. Predictors included patient and disease characteristics and drug utilization. Potential predictors were identified through an expert panel and published literature. We estimated adjusted effect estimates with 95% confidence intervals using logistic and zero-inflated Poisson regression.
RESULTS: Overall, 699 (58.9%) experienced Crohn's disease and 488 (41.1%) had ulcerative colitis. Most important predictors for temporary work disability in patients with Crohn's disease included gender, disease duration, disease activity, C-reactive protein level, smoking, depressive symptoms, fistulas, extraintestinal manifestations, and the use of immunosuppressants/steroids. Temporary work disability in patients with ulcerative colitis was associated with age, disease duration, disease activity, and the use of steroids/antibiotics. In all patients, disease activity emerged as the only predictor of permanent work disability. Comparing data at enrollment versus follow-up yielded substantial differences regarding disability and predictors, with follow-up data showing greater predictor effects.
CONCLUSIONS: We identified predictors of work disability in patients with Crohn's disease and ulcerative colitis. Our findings can help in forecasting these disease courses and guide the choice of appropriate measures to prevent adverse outcomes. Comparing cross-sectional and longitudinal data showed that the conduction of cohort studies is inevitable for the examination of disability.
Keywords
Adult, Colitis, Ulcerative/diagnosis, Colitis, Ulcerative/epidemiology, Crohn Disease/diagnosis, Crohn Disease/epidemiology, Disabled Persons/psychology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Switzerland/epidemiology, Work Capacity Evaluation
Pubmed
Web of science
Create date
07/02/2014 16:00
Last modification date
20/08/2019 13:32
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