Elevation of NT-proBNP and cardiac troponins in sepsis-related deaths: a forensic perspective.

Détails

ID Serval
serval:BIB_0A89002A06FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Elevation of NT-proBNP and cardiac troponins in sepsis-related deaths: a forensic perspective.
Périodique
International journal of legal medicine
Auteur(s)
Tettamanti C., Hervet T., Grabherr S., Palmiere C.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
130
Numéro
4
Pages
1035-1043
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In the present study, the levels of NT-proBNP, troponin T, and troponin I were measured in postmortem serum from femoral blood in a series of sepsis-related fatalities that had undergone forensic autopsies. We aimed to assess whether a possible increase in the concentrations of these biomarkers was correlated to macroscopic or microscopic observations that suggest myocardial damage or cardiac dysfunction. Two study groups were retrospectively formed, a sepsis-related fatalities group and a control group. Both groups consisted of 16 forensic autopsy cases. Unenhanced computed tomography scan, autopsy, histological, toxicological, microbiological, and biochemical analyses were performed for all cases in both groups. Levels of procalcitonin, C-reactive protein, NT-proBNP, troponin T, and troponin I were systematically measured in postmortem serum from femoral blood. The preliminary results suggest that the postmortem serum troponin I, troponin T, and NT-proBNP levels are increased in sepsis-related deaths in the absence of any relevant coronary artery disease, myocardial ischemia, or signs of heart failure. These findings corroborate clinical data from previous studies pertaining to the usefulness of troponins and natriuretic peptides as indicators of toxic and inflammatory damage to the heart in cases of severe sepsis and septic shock without concomitant underlying coronary syndromes.

Mots-clé
Adult, Aged, Aged, 80 and over, Biomarkers/blood, C-Reactive Protein/analysis, Calcitonin/blood, Case-Control Studies, Female, Humans, Male, Middle Aged, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Retrospective Studies, Sepsis/blood, Troponin I/blood, Troponin T/blood, Autopsy, Cardiac biomarkers, Postmortem biochemistry, Sepsis
Pubmed
Web of science
Création de la notice
29/03/2016 12:58
Dernière modification de la notice
20/08/2019 13:32
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