Pharmacokinetic-pharmacodynamic modelling: history and perspectives

Détails

ID Serval
serval:BIB_0A767B031ED3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pharmacokinetic-pharmacodynamic modelling: history and perspectives
Périodique
Journal of Pharmacokinetics and Pharmacodynamics
Auteur(s)
Csajka  C., Verotta  D.
ISSN
1567-567X (Print)
Statut éditorial
Publié
Date de publication
06/2006
Volume
33
Numéro
3
Pages
227-79
Notes
Historical Article
Journal Article
Research Support, N.I.H., Extramural
Review --- Old month value: Jun
Résumé
A major goal in clinical pharmacology is the quantitative prediction of drug effects. The field of pharmacokinetic-pharmacodynamic (PK/PD) modelling has made many advances from the basic concept of the dose-response relationship to extended mechanism-based models. The purpose of this article is to review, from a historical perspective, the progression of the modelling of the concentration-response relationship from the first classic models developed in the mid-1960s to some of the more sophisticated current approaches. The emphasis is on general models describing key PD relationships, such as: simple models relating drug dose or concentration in plasma to effect, biophase distribution models and in particular effect compartment models, models for indirect mechanism of action that involve primarily the modulation of endogenous factors, models for cell trafficking and transduction systems. We show the evolution of tolerance and time-variant models, non- and semi-parametric models, and briefly discuss population PK/PD modelling, together with some example of more recent and complex pharmacodynamic models for control system and nonlinear HIV-1 dynamics. We also discuss some future possible directions for PK/PD modelling, report equations for general classes of novel semi-parametric models, as well as describing two new classes, additive or set-point, of regulatory, additive feedback models in their direct and indirect action variants.
Mots-clé
Algorithms Computing Methodologies HIV Infections/drug therapy HIV-1/drug effects History, 20th Century History, 21st Century Humans *Models, Biological *Pharmacokinetics Pharmacology/*history/trends
Pubmed
Web of science
Création de la notice
25/01/2008 11:48
Dernière modification de la notice
03/03/2018 13:34
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