Negative effect of vitamin D on kidney function: a Mendelian randomization study.

Details

Serval ID
serval:BIB_0A4B9D480496
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Negative effect of vitamin D on kidney function: a Mendelian randomization study.
Journal
Nephrology, dialysis, transplantation
Author(s)
Teumer A., Gambaro G., Corre T., Bochud M., Vollenweider P., Guessous I., Kleber M.E., Delgado G.E., Pilz S., März W., Barnes CLK, Joshi P.K., Wilson J.F., de Borst M.H., Navis G., van der Harst P., Heerspink HJL, Homuth G., Endlich K., Nauck M., Köttgen A., Pattaro C., Ferraro P.M.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
01/12/2018
Peer-reviewed
Oui
Volume
33
Number
12
Pages
2139-2145
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The kidney plays a central role in the regulation of vitamin D metabolism. It is not clear, however, whether vitamin D influences kidney function. Previous studies have reported conflicting results, which may have been influenced by reverse causation and residual confounding. We conducted a Mendelian randomization (MR) study to obtain unconfounded estimates of the association between genetically instrumented vitamin D metabolites and estimated glomerular filtration rate (eGFR) as well as the urinary albumin:creatinine ratio (UACR).
We performed a two-sample MR study based on three single nucleotide variants associated with 25(OH)D levels: rs2282679, rs10741657 and rs12785878, related to the genes GC, CYP2R1 and DHCR7, respectively. Estimates of the allele-dependent effects on serum 25(OH)D and eGFR/UACR were obtained from summary statistics of published genome-wide association meta-analyses. Additionally, we performed a one-sample MR analysis for both 25(OH)D and 1,25(OH)2 D using individual-level data from six cohorts.
The combined MR estimate supported a negative causal effect of log transformed 25(OH)D on log transformed eGFR (β = -0.013, P = 0.003). The analysis of individual-level data confirmed the main findings and also revealed a significant association of 1,25(OH)2 D on eGFR (β = -0.094, P = 0.008). These results show that a 10% increase in serum 25(OH)D levels causes a 0.3% decrease in eGFR. There was no effect of 25(OH)D on UACR (β = 0.032, P = 0.265).
Our study suggests that circulating vitamin D metabolite levels are negatively associated with eGFR. Further studies are needed to elucidate the underlying mechanisms.
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Web of science
Create date
03/05/2018 16:17
Last modification date
20/08/2019 12:32
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