What do we know about gliotransmitter release from astrocytes?

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_0A003CA9E5BB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
What do we know about gliotransmitter release from astrocytes?
Périodique
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Auteur(s)
Sahlender D.A., Savtchouk I., Volterra A.
ISSN
1471-2970 (Electronic)
ISSN-L
0962-8436
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
369
Numéro
1654
Pages
20130592
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Astrocytes participate in information processing by actively modulating synaptic properties via gliotransmitter release. Various mechanisms of astrocytic release have been reported, including release from storage organelles via exocytosis and release from the cytosol via plasma membrane ion channels and pumps. It is still not fully clear which mechanisms operate under which conditions, but some of them, being Ca(2+)-regulated, may be physiologically relevant. The properties of Ca(2+)-dependent transmitter release via exocytosis or via ion channels are different and expected to produce different extracellular transmitter concentrations over time and to have distinct functional consequences. The molecular aspects of these two release pathways are still under active investigation. Here, we discuss the existing morphological and functional evidence in support of either of them. Transgenic mouse models, specific antagonists and localization studies have provided insight into regulated exocytosis, albeit not in a systematic fashion. Even more remains to be uncovered about the details of channel-mediated release. Better functional tools and improved ultrastructural approaches are needed in order fully to define specific modalities and effects of astrocytic gliotransmitter release pathways.
Pubmed
Web of science
Création de la notice
13/01/2015 11:14
Dernière modification de la notice
03/03/2018 13:33
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