Article: article from journal or magazin.
Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics.
Journal of Biological Chemistry
Publication types: Comparative Study ; Journal Article
Advances in wound care are of great importance in clinical injury management. In this respect, the nuclear receptor peroxisome proliferator-activated receptor (PPAR)beta/delta occupies a unique position at the intersection of diverse inflammatory or anti-inflammatory signals that influence wound repair. This study shows how changes in PPARbeta/delta expression have a profound effect on wound healing. Using two different in vivo models based on topical application of recombinant transforming growth factor (TGF)-beta1 and ablation of the Smad3 gene, we show that prolonged expression and activity of PPARbeta/delta accelerate wound closure. The results reveal a dual role of TGF-beta1 as a chemoattractant of inflammatory cells and repressor of inflammation-induced PPARbeta/delta expression. Also, they provide insight into the so far reported paradoxical effects of the application of exogenous TGF-beta1 at wound sites.
Administration, Topical, Animals, Epidermis/metabolism, Epidermis/physiology, Female, Gene Expression Regulation/physiology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, PPAR delta/biosynthesis, PPAR delta/deficiency, PPAR-beta/biosynthesis, PPAR-beta/deficiency, Signal Transduction/genetics, Signal Transduction/physiology, Transforming Growth Factor beta/administration & dosage, Transforming Growth Factor beta/physiology, Transforming Growth Factor beta1, Wound Healing/genetics, Wound Healing/physiology
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