Dysfonction visuelle et occlusion artérielle: association à la mutation Leiden du facteur V? A propos de 4 cas [Visual dysfunction and arterial occlusion: is there an association with factor V Leiden mutation? Four case reports]

Détails

ID Serval
serval:BIB_09C08BBC19FB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Dysfonction visuelle et occlusion artérielle: association à la mutation Leiden du facteur V? A propos de 4 cas [Visual dysfunction and arterial occlusion: is there an association with factor V Leiden mutation? Four case reports]
Périodique
Journal français d'ophtalmologie
Auteur(s)
Bessero A.C., Borruat F.X.
ISSN
1773-0597[electronic]
Statut éditorial
Publié
Date de publication
01/2006
Peer-reviewed
Oui
Volume
29
Numéro
1
Pages
43-6
Langue
français
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Publication Status: ppublish
Résumé
INTRODUCTION: The Leiden mutation of the factor V gene and the subsequent resistance of factor V to inactivation by activated protein C are associated with a procoagulant state, especially in the venous bed. However, its association with arterial thrombotic disease remains unclear. OBSERVATIONS: We report four patients with visual field defects secondary to arterial occlusions and in whom we found a factor V Leiden mutation. These patients, three females and one male, aged 32-58 years, presented with various visual field defects: bilateral arciform scotomas due to multiple infarcts of the nerve fiber layer (one case), superior defect due to anterior ischemic optic neuropathy (one case), homonymous hemianopia due to stroke (two cases). An abnormal resistance to activated protein C and a heterozygous state for factor V Leiden mutation were found in all four cases. The two patients who suffered from a stroke also showed elevated antiphospholipid antibodies (one case) and a patent foramen ovale (one case). COMMENTS AND CONCLUSION: Conflicting reports on the effective role of factor V Leiden mutation in arterial thrombotic events are present in the literature. We report four cases of arterial occlusion in whom a thrombophilic predisposition was present with a heterozygous state for factor V Leiden mutation. In two cases, no other risk factor was found. We hypothesize that factor V Leiden mutation, even in a heterozygous state, might predispose to arterial occlusion in some patients.
Mots-clé
Adult, Arterial Occlusive Diseases/complications, Arterial Occlusive Diseases/genetics, Factor V/genetics, Female, Humans, Male, Middle Aged, Point Mutation, Vision Disorders/etiology, Vision Disorders/genetics, Visual Fields
Pubmed
Web of science
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
20/08/2019 12:31
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