Role for the amino-terminal region of human TBP in U6 snRNA transcription.

Détails

ID Serval
serval:BIB_09BE1E915AB8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Role for the amino-terminal region of human TBP in U6 snRNA transcription.
Périodique
Science
Auteur(s)
Mittal V., Hernandez N.
ISSN
0036-8075[print], 0036-8075[linking]
Statut éditorial
Publié
Date de publication
02/1997
Volume
275
Numéro
5303
Pages
1136-1140
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Basal transcription from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc). TBP consists of a conserved carboxyl-terminal domain that performs all known functions of the protein and a nonconserved amino-terminal region of unknown function. Here, the amino-terminal region is shown to down-regulate binding of TBP to the U6 TATA box, mediate cooperative binding with SNAPc to the U6 promoter, and enhance U6 transcription.
Mots-clé
Amino Acid Sequence, DNA Footprinting, DNA-Binding Proteins/chemistry, DNA-Binding Proteins/genetics, Down-Regulation, Humans, Molecular Sequence Data, Promoter Regions, Genetic, Proteins/metabolism, RNA, Small Nuclear/genetics, RNA-Binding Proteins/metabolism, Recombinant Fusion Proteins/chemistry, Recombinant Fusion Proteins/metabolism, TATA Box, TATA-Box Binding Protein, Transcription Factors/chemistry, Transcription Factors/genetics, Transcription, Genetic
Pubmed
Web of science
Création de la notice
21/01/2008 17:33
Dernière modification de la notice
20/08/2019 13:31
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