Antigen sampling across epithelial barriers and induction of mucosal immune responses

Détails

ID Serval
serval:BIB_09811DC3E56C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antigen sampling across epithelial barriers and induction of mucosal immune responses
Périodique
Annual Review of Immunology
Auteur(s)
Neutra  M. R., Pringault  E., Kraehenbuhl  J. P.
ISSN
0732-0582 (Print)
Statut éditorial
Publié
Date de publication
1996
Volume
14
Pages
275-300
Notes
Journal Article
Review
Résumé
Epithelial barriers on mucosal surfaces at different sites in the body differ dramatically in their cellular organization, and antigen sampling strategies at diverse mucosal sites are adapted accordingly. In stratified and pseudostratified epithelia, dendritic cells migrate to the outer limit of the epithelium, where they sample antigens for subsequent presentation in local or distant organized lymphoid tissues. In simple epithelia, specialized epithelial M cells (a phenotype that occurs only in the epithelium over organized lymphoid follicles) deliver samples of foreign material by transepithelial transport from the lumen to organized lymphoid tissues within the mucosa. Certain pathogens exploit the M cell transport process to cross the epithelial barrier and invade the mucosa. Here we review the features of M cells that determine antigen and pathogen adherence and transport into mucosal lymphoid tissues.
Mots-clé
Animals Biological Transport/immunology Cell Communication/*immunology Epithelium/immunology Humans *Immunity, Mucosal
Pubmed
Web of science
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
03/03/2018 13:31
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