Article: article d'un périodique ou d'un magazine.
Predicting time to ovarian carcinoma recurrence using protein markers.
Journal of Clinical Investigation
Cancer Genome Atlas (TCGA) Research Network
Date de publication
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural Publication Status: ppublish
Patients with ovarian cancer are at high risk of tumor recurrence. Prediction of therapy outcome may provide therapeutic avenues to improve patient outcomes. Using reverse-phase protein arrays, we generated ovarian carcinoma protein expression profiles on 412 cases from TCGA and constructed a PRotein-driven index of OVARian cancer (PROVAR). PROVAR significantly discriminated an independent cohort of 226 high-grade serous ovarian carcinomas into groups of high risk and low risk of tumor recurrence as well as short-term and long-term survivors. Comparison with gene expression-based outcome classification models showed a significantly improved capacity of the protein-based PROVAR to predict tumor progression. Identification of protein markers linked to disease recurrence may yield insights into tumor biology. When combined with features known to be associated with outcome, such as BRCA mutation, PROVAR may provide clinically useful predictions of time to tumor recurrence.
Adult, Aged, Aged, 80 and over, Cluster Analysis, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Multivariate Analysis, Neoplasm Proteins/metabolism, Neoplasm Recurrence, Local/metabolism, Neoplasm Recurrence, Local/mortality, Neoplasms, Glandular and Epithelial/metabolism, Neoplasms, Glandular and Epithelial/mortality, Ovarian Neoplasms/metabolism, Ovarian Neoplasms/mortality, Prognosis, Proportional Hazards Models, Proteomics, Risk, Transcriptome, Tumor Markers, Biological/metabolism
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