Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_08FFB623B3A8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations.
Périodique
European Journal of Epidemiology
Auteur(s)
Rossi I.A., Bochud M., Bovet P., Paccaud F., Waeber G., Vollenweider P., Taffé P.
ISSN
1573-7284 (Electronic)
ISSN-L
0393-2990
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
27
Numéro
5
Pages
379-384
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated and correlations are stronger in women than men. We used fractional polynomials-a method that allows flexible modeling of non linear relations-to investigate the dose/response mathematical relationship between hs-CRP and several indicators of adiposity in Caucasians (Switzerland) and Africans (Seychelles) surveyed in two population-based studies. This relationship was non-linear exhibiting a steeper slope for low levels of hs-CRP and a higher level in women. The observed sex difference in the relationship between hs-CRP and adiposity almost disappeared upon adjustment for leptin, suggesting that these sex differences might be partially mediated, by leptin. All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity.
Pubmed
Web of science
Création de la notice
02/05/2012 15:26
Dernière modification de la notice
03/03/2018 13:31
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