Chromatin movement in the maintenance of genome stability.

Détails

ID Serval
serval:BIB_08C58978C573
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Chromatin movement in the maintenance of genome stability.
Périodique
Cell
Auteur(s)
Dion V., Gasser S.M.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2013
Volume
152
Numéro
6
Pages
1355-1364
Langue
anglais
Résumé
Mechanistic analyses based on improved imaging techniques have begun to explore the biological implications of chromatin movement within the nucleus. Studies in both prokaryotes and eukaryotes have shed light on what regulates the mobility of DNA over long distances. Interestingly, in eukaryotes, genomic loci increase their movement in response to double-strand break induction. Break mobility, in turn, correlates with the efficiency of repair by homologous recombination. We review here the source and regulation of DNA mobility and discuss how it can both contribute to and jeopardize genome stability.
Mots-clé
Animals, Chromatin/chemistry, Chromatin/metabolism, DNA/metabolism, DNA Damage, DNA Repair, Genomic Instability, Humans, Movement, Transcription, Genetic
Pubmed
Web of science
Création de la notice
12/02/2014 16:30
Dernière modification de la notice
03/03/2018 13:30
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