The clinical application of converting enzyme inhibitors.

Details

Serval ID
serval:BIB_08B716F59DCC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The clinical application of converting enzyme inhibitors.
Journal
Clinical and experimental hypertension. Part A, Theory and practice
Author(s)
Brunner H.R., Turini G.A., Waeber B., Nussberger J., Biollaz J.
ISSN
1064-1963
0730-0077
Publication state
Published
Issued date
1983
Volume
5
Number
7-8
Pages
1355-66
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
Chronic blockade of the renin angiotensin system became possible when orally active inhibitors of angiotensin converting enzyme, the enzyme which catalyzes the transformation of angiotensin I into angiotensin II, were synthetized. Two compounds, captopril and enalapril, have been investigated in clinical studies. The decrease of the pressor response to exogenous angiotensin I and of the circulating levels of angiotensin II following administration of these inhibitors has been demonstrated to be directly related to the degree of suppression of plasma angiotensin converting enzyme activity. These inhibitors have been shown to normalize blood pressure alone in some hypertensive patients whereas in many others, satisfactory blood pressure control can be achieved only after the addition of a diuretic. Captopril and enalapril also markedly improve cardiac function of patients with chronic congestive heart failure. Chronic blockade of the renin angiotensin system has therefore provided an interesting new approach to the treatment of clinical hypertension and heart failure.
Keywords
Angiotensin-Converting Enzyme Inhibitors, Drug Tolerance, Heart Failure, Humans, Hypertension, Renin, Renin-Angiotensin System
Pubmed
Web of science
Create date
25/01/2008 10:41
Last modification date
20/08/2019 12:31
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