Variable corticosteroid sensitivity of thymic cortex and medullary peripheral-type lymphoid tissue in myasthenia gravis patients: structural and functional effects

Détails

ID Serval
serval:BIB_085F7DAF07D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Variable corticosteroid sensitivity of thymic cortex and medullary peripheral-type lymphoid tissue in myasthenia gravis patients: structural and functional effects
Périodique
Quarterly Journal of Medicine
Auteur(s)
Willcox  N., Schluep  M., Sommer  N., Campana  D., Janossy  G., Brown  A. N., Newsom-Davis  J.
ISSN
1460-2725
0033-5622 (Print)
Statut éditorial
Publié
Date de publication
11/1989
Volume
73
Numéro
271
Pages
1071-87
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
The thymus has been studied in myasthenia gravis patients to assess the effects of previous immunosuppression on total yields of cell suspension, immunohistology and culture responses. The reduction in cell yields by pretreatment with corticosteroid was very variable. In 16 of 32 cases, cortical, medullary and total cell numbers were all greatly reduced ('depleted cases'), whereas in the others, they were within or near the typical range for untreated myasthenics. Cortical thymocytes were even more depleted than precursor thymic blasts. Thus the interpatient differences in sensitivity to corticosteroid recently described for mature T cells also affected immature cortical thymocytes and their differentiating medullary progeny. In the medulla, mature (CD3+) T lymphocytes and germinal centres were enriched by the loss of cortex and appeared relatively healthy, but somewhat depopulated. Concomitantly, in-vitro T-cell responses to acetylcholine receptor (AChR) and production of anti-AChR antibody and total IgG by thymic cells were usually well within the typical range (assessed per 10(6) cells). Moreover, the total productivity of the entire thymus was reduced almost entirely by the cellular depopulation rather than by decreased function per surviving cell. Thus the main actions of this alternate day therapy with corticosteroids were apparently on total peripheral cell numbers, and perhaps on activated cells and effector mechanisms too, and its thymic effects were inessential.
Mots-clé
Adolescent Adrenal Cortex Hormones/*therapeutic use Adult Autoantibodies/analysis Cells, Cultured Female Humans Immunoglobulin G/analysis Immunohistochemistry Male Myasthenia Gravis/drug therapy/immunology/*pathology Receptors, Cholinergic/immunology T-Lymphocytes/immunology Thymus Gland/drug effects/immunology/*pathology
Pubmed
Web of science
Création de la notice
25/01/2008 13:46
Dernière modification de la notice
03/03/2018 13:29
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