Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.

Détails

ID Serval
serval:BIB_0859BAFEE78F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
Périodique
Brain and Language
Auteur(s)
Péran P., Nemmi F., Méligne D., Cardebat D., Peppe A., Rascol O., Caltagirone C., Demonet J.F., Sabatini U.
ISSN
1090-2155 (Electronic)
ISSN-L
0093-934X
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
125
Numéro
3
Pages
324-329
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Previous studies have demonstrated that non-demented Parkinson's disease (PD) patients have a specific impairment of verb production compared with noun generation. One interpretation of this deficit suggested the influence of striato-frontal dysfunction on action-related verb processing. The aim of our study was to investigate cerebral changes after motor improvement due to dopaminergic medication on the neural circuitry supporting action representation in the brain as mediated by verb generation and motor imagery in PD patients. Functional magnetic resonance imaging on 8 PD patients in "ON" dopaminergic treatment state (DTS) and in "OFF" DTS was used to explore the brain activity during three different tasks: Object Naming (ObjN), Generation of Action Verbs (GenA) in which patients were asked to overtly say an action associated with a picture and mental simulation of action (MSoA) was investigated by asking subjects to mentally simulate an action related to a depicted object. The distribution of brain activities associated with these tasks whatever DTS was very similar to results of previous studies. The results showed that brain activity related to semantics of action is modified by dopaminergic treatment in PD patients. This cerebral reorganisation concerns mainly motor and premotor cortex suggesting an involvement of the putaminal motor loop according to the "motor" theory of verb processing.
Pubmed
Web of science
Création de la notice
24/03/2013 11:26
Dernière modification de la notice
20/08/2019 13:30
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