Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.

Détails

Ressource 1Télécharger: s12967-017-1227-3.pdf (1791.82 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_0840277CD209
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.
Périodique
Journal of translational medicine
Auteur(s)
Ghassem-Zadeh S., Gaida M.M., Szanyi S., Acha-Orbea H., Frossard J.L., Hinz U., Hackert T., Strobel O., Felix K.
ISSN
1479-5876 (Electronic)
ISSN-L
1479-5876
Statut éditorial
Publié
Date de publication
02/06/2017
Peer-reviewed
Oui
Volume
15
Numéro
1
Pages
126
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Discriminating between autoimmune pancreatitis (AIP), chronic pancreatitis (CP), and pancreatic ductal adenocarcinoma (PDAC) can be challenging. In this retrospective study, levels of serum and tissue cytokines were analyzed as part of the clinical strategy for the preoperative differentiation between AIP and PDAC. The identification of differential cytokine profiles may help to prevent unnecessary surgical resection and allow optimal treatment of these pathologies.
To compare the cytokine profiles of AIP, CP, and PDAC patients, serum and pancreatic tissue homogenates were subjected to multiplex analysis of 17 inflammatory mediators. In total, serum from 73 patients, composed of 29 AIP (14 AIP-1 and 15 AIP-2), 17 CP, and 27 PDAC, and pancreatic tissue from 36 patients, including 12 AIP (six AIP-1 and six AIP-2), 12 CP, and 12 PDAC, were analyzed.
Comparing AIP and PDAC patients' serum, significantly higher concentrations were found in AIP for interleukins IL-1β, IL-7, IL-13, and granulocyte colony-stimulating factor (G-CSF). G-CSF also allowed discrimination of AIP from CP. Furthermore, once AIP was divided into subtypes, significantly higher serum levels for IL-7 and G-CSF were measured in both subtypes of AIP and in AIP-2 for IL-1β when compared to PDAC. G-CSF and TNF-α were also significantly differentially expressed in tissue homogenates between AIP-2 and PDAC.
The cytokines IL-1β, IL-7, and G-CSF can be routinely measured in patients' serum, providing an elegant and non-invasive approach for differential diagnosis. G-CSF is a good candidate to supplement the currently known serum markers in predictive tests for AIP and represents a basis for a combined blood test to differentiate AIP and particularly AIP-2 from PDAC, enhancing the possibility of appropriate treatment.

Mots-clé
Adenocarcinoma/blood, Adenocarcinoma/diagnosis, Adenocarcinoma/physiopathology, Adult, Autoimmune Diseases/blood, Autoimmune Diseases/diagnosis, Autoimmune Diseases/physiopathology, Carcinoma, Pancreatic Ductal/blood, Carcinoma, Pancreatic Ductal/diagnosis, Carcinoma, Pancreatic Ductal/physiopathology, Cytokines/blood, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms/blood, Pancreatic Neoplasms/diagnosis, Pancreatitis, Chronic/blood, Pancreatitis, Chronic/diagnosis, Pancreatitis, Chronic/physiopathology, ROC Curve, Autoimmune pancreatitis type 1 and type 2, Chronic pancreatitis, Cytokines, Pancreatic ductal adenocarcinoma
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/06/2017 21:42
Dernière modification de la notice
20/08/2019 13:30
Données d'usage