Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor.

Details

Serval ID
serval:BIB_083AACA66516
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor.
Journal
Journal of immunology
Author(s)
Tabiasco J., Devêvre E., Rufer N., Salaun B., Cerottini J.C., Speiser D., Romero P.
ISSN
0022-1767
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
177
Number
12
Pages
8708-8713
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
TLR are evolutionarily conserved molecules that play a key role in the initiation of innate antimicrobial immune responses. Through their influence on dendritic cell maturation, these receptors are also thought to indirectly shape the adaptive immune response. However, no data are currently available regarding both TLR expression and function in human CD8+ T cell subsets. We report that a subpopulation of CD8+ T cells, i.e., effector, but neither naive nor central memory cells, constitutively expresses TLR3. Moreover, the ligation of the receptor by a specific agonist in TLR3-expressing CD8+ T cells increased IFN-gamma secretion induced by TCR-dependent and -independent stimulation, without affecting proliferation or specific cytolytic activity. These results thereby suggest that TLR3 ligands can not only indirectly influence the adaptive immune response through modulation of dendritic cell activation, but also directly increase IFN-gamma production by Ag-specific CD8+ T cells. Altogether, the present work might open new perspectives for the use of TLR ligands as adjuvants for immunotherapy.
Keywords
CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Proliferation, Cytotoxicity, Immunologic, Humans, Immunity, Innate, Interferon-gamma/secretion, Ligands, T-Cell Antigen Receptor Specificity, Toll-Like Receptor 3/agonists, Toll-Like Receptor 3/immunology
Pubmed
Web of science
Create date
28/01/2008 11:14
Last modification date
20/08/2019 12:30
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