Mechanistic insights into m<sup>6</sup>A RNA enzymes.

Détails

ID Serval
serval:BIB_08184FD62D7B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Mechanistic insights into m<sup>6</sup>A RNA enzymes.
Périodique
Biochimica et biophysica acta. Gene regulatory mechanisms
Auteur(s)
Lence T., Paolantoni C., Worpenberg L., Roignant J.Y.
ISSN
1876-4320 (Electronic)
ISSN-L
1874-9399
Statut éditorial
Publié
Date de publication
03/2019
Peer-reviewed
Oui
Volume
1862
Numéro
3
Pages
222-229
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The field of RNA modifications, so-called epitranscriptomics, has flourished over the past years owing to improvements of detection methods and the identification of important regulatory players. N6-methyladenosine (m <sup>6</sup> A) is the most abundant internal modification in messenger (mRNA) and long non-coding (lncRNA), and controls most steps of RNA metabolism. Its physiological roles range from gametogenesis, stem cell differentiation to immunity, neuronal development and functions, while its alterations are associated with cancer development and progression. In this review we focus on the proteins that catalyze formation of m <sup>6</sup> A (also called writers) on RNA. Interestingly, distinct proteins deposit m <sup>6</sup> A on different classes of RNA, indicating that specific RNA features dictate recognition mechanisms. Associated factors and post-translational modifications can also alter m <sup>6</sup> A enzyme activity. A better understanding of the underlying regulation involved in m <sup>6</sup> A deposition is the first step towards developing tools for cancer therapy and for treatment of other m <sup>6</sup> A-associated diseases.
Mots-clé
Adenosine/analogs & derivatives, Adenosine/chemistry, Adenosine/metabolism, Animals, Catalytic Domain, Gene Expression Regulation, Developmental, Humans, Methyltransferases/chemistry, Methyltransferases/metabolism, RNA Processing, Post-Transcriptional, RNA, Messenger/chemistry, RNA, Messenger/metabolism, MAC, MACOM, Mettl16, Mettl3, RNA modifications, RlmJ, m(6)A
Pubmed
Web of science
Création de la notice
28/10/2019 12:36
Dernière modification de la notice
29/10/2019 6:26
Données d'usage