Mechanistic insights into m6A RNA enzymes.

Details

Serval ID
serval:BIB_08184FD62D7B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mechanistic insights into m6A RNA enzymes.
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
Author(s)
Lence T., Paolantoni C., Worpenberg L., Roignant J.Y.
ISSN
1876-4320 (Electronic)
ISSN-L
1874-9399
Publication state
Published
Issued date
03/2019
Peer-reviewed
Oui
Volume
1862
Number
3
Pages
222-229
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The field of RNA modifications, so-called epitranscriptomics, has flourished over the past years owing to improvements of detection methods and the identification of important regulatory players. N6-methyladenosine (m <sup>6</sup> A) is the most abundant internal modification in messenger (mRNA) and long non-coding (lncRNA), and controls most steps of RNA metabolism. Its physiological roles range from gametogenesis, stem cell differentiation to immunity, neuronal development and functions, while its alterations are associated with cancer development and progression. In this review we focus on the proteins that catalyze formation of m <sup>6</sup> A (also called writers) on RNA. Interestingly, distinct proteins deposit m <sup>6</sup> A on different classes of RNA, indicating that specific RNA features dictate recognition mechanisms. Associated factors and post-translational modifications can also alter m <sup>6</sup> A enzyme activity. A better understanding of the underlying regulation involved in m <sup>6</sup> A deposition is the first step towards developing tools for cancer therapy and for treatment of other m <sup>6</sup> A-associated diseases.
Keywords
Adenosine/analogs & derivatives, Adenosine/chemistry, Adenosine/metabolism, Animals, Catalytic Domain, Gene Expression Regulation, Developmental, Humans, Methyltransferases/chemistry, Methyltransferases/metabolism, RNA Processing, Post-Transcriptional, RNA, Messenger/chemistry, RNA, Messenger/metabolism, MAC, MACOM, Mettl16, Mettl3, RNA modifications, RlmJ, m(6)A
Pubmed
Web of science
Create date
28/10/2019 12:36
Last modification date
13/03/2024 14:38
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