Associations between alcohol consumption and selected cytokines in a Swiss population-based sample (CoLaus study).

Détails

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Etat: Supprimée
Version: de l'auteur
ID Serval
serval:BIB_0817B7CF75BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Associations between alcohol consumption and selected cytokines in a Swiss population-based sample (CoLaus study).
Périodique
Atherosclerosis
Auteur(s)
Marques-Vidal P., Bochud M., Bastardot F., von Känel R., Ferrero F., Gaspoz J.M., Paccaud F., Urwyler A., Lüscher T., Hock C., Waeber G., Preisig M., Vollenweider P.
ISSN
1879-1484 (Electronic)
ISSN-L
0021-9150
Statut éditorial
Publié
Date de publication
05/2012
Peer-reviewed
Oui
Volume
222
Numéro
1
Pages
245-250
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To assess the associations between alcohol consumption and cytokine levels (interleukin-1beta - IL-1β; interleukin-6 - IL-6 and tumor necrosis factor-α - TNF-α) in a Caucasian population.
Population sample of 2884 men and 3201 women aged 35-75. Alcohol consumption was categorized as nondrinkers, low (1-6 drinks/week), moderate (7-13/week) and high (14+/week).
No difference in IL-1β levels was found between alcohol consumption categories. Low and moderate alcohol consumption led to lower IL-6 levels: median (interquartile range) 1.47 (0.70-3.51), 1.41 (0.70-3.32), 1.42 (0.66-3.19) and 1.70 (0.83-4.39) pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p<0.01, but this association was no longer significant after multivariate adjustment. Compared to nondrinkers, moderate drinkers had the lowest odds (Odds ratio=0.86 (0.71-1.03)) of being in the highest quartile of IL-6, with a significant (p<0.05) quadratic trend. Low and moderate alcohol consumption led to lower TNF-α levels: 2.92 (1.79-4.63), 2.83 (1.84-4.48), 2.82 (1.76-4.34) and 3.15 (1.91-4.73) pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p<0.02, and this difference remained borderline significant (p=0.06) after multivariate adjustment. Moderate drinkers had a lower odds (0.81 [0.68-0.98]) of being in the highest quartile of TNF-α. No specific alcoholic beverage (wine, beer or spirits) effect was found.
Moderate alcohol consumption is associated with lower levels of IL-6 and (to a lesser degree) of TNF-α, irrespective of the type of alcohol consumed. No association was found between IL-1β levels and alcohol consumption.

Mots-clé
Adult, Aged, Alcohol Drinking, European Continental Ancestry Group, Female, Humans, Interleukin-1beta/blood, Interleukin-6/blood, Male, Middle Aged, Switzerland, Tumor Necrosis Factor-alpha/blood
Pubmed
Web of science
Création de la notice
19/03/2012 14:44
Dernière modification de la notice
20/08/2019 13:30
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