Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.

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ID Serval
serval:BIB_080285A21A74
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.
Périodique
Neuron
Auteur(s)
Trusel M., Nuno-Perez A., Lecca S., Harada H., Lalive A.L., Congiu M., Takemoto K., Takahashi T., Ferraguti F., Mameli M.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
102
Numéro
1
Pages
120-127.e4
Langue
anglais
Résumé
Throughout life, individuals learn to predict a punishment via its association with sensory stimuli. This process ultimately prompts goal-directed actions to prevent the danger, a behavior defined as avoidance. Neurons in the lateral habenula (LHb) respond to aversive events as well as to environmental cues predicting them, supporting LHb contribution to cue-punishment association. However, whether synaptic adaptations at discrete habenular circuits underlie such associative learning to instruct avoidance remains elusive. Here, we find that, in mice, contingent association of an auditory cue (tone) with a punishment (foot shock) progressively causes cue-driven LHb neuronal excitation during avoidance learning. This process is concomitant with the strengthening of LHb AMPA receptor-mediated neurotransmission. Such a phenomenon occludes long-term potentiation and occurs specifically at hypothalamus-to-habenula synapses. Silencing hypothalamic-to-habenulainputs or optically inactivating postsynaptic AMPA receptors within the LHb disrupts avoidance learning. Altogether, synaptic strengthening at a discrete habenular circuit transforms neutral stimuli into salient punishment-predictive cues to guide avoidance.
Mots-clé
AMPA receptors, avoidance, lateral habenula, long-term potentiation
Pubmed
Web of science
Création de la notice
31/03/2019 15:31
Dernière modification de la notice
20/08/2019 13:30
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