Torsade de pointe: un effet secondaire grave et méconnu chez le toxicomane sous méthadone. [Torsade de pointes: a severe and unknown adverse effect in a patient taking methadone]

Détails

ID Serval
serval:BIB_0754B99D882D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Torsade de pointe: un effet secondaire grave et méconnu chez le toxicomane sous méthadone. [Torsade de pointes: a severe and unknown adverse effect in a patient taking methadone]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur(s)
Vodoz  J. F., Jaquier  F., Lamy  O.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
10/2003
Volume
92
Numéro
41
Pages
1748-50
Notes
Case Reports Comparative Study English Abstract Journal Article --- Old month value: Oct 8
Résumé
We present here the case of a young drug-addicted patient, who showed a cardio-respiratory arrest attributed to a torsade de pointe-type ventricular arrhythmia. After excluding the usual causes of such arrhythmia, we concluded that it was consecutive to high-dose methadone intake. Methadone can induce torsade de pointe through two mechanisms: a QT interval prolongation secondary to a bradycardia or a prolongation of the myocardial action potential. When prescribing methadone, one should avoid association with other CYP3A4 inhibiting drugs and, if higher doses are necessary, perform regular EKG screening.
Mots-clé
Adult Cytochrome P-450 Enzyme System/metabolism Diagnosis, Differential Electrocardiography Humans Male Methadone/administration & dosage/*adverse effects Monitoring, Physiologic Narcotics/administration & dosage/*adverse effects Substance-Related Disorders/*rehabilitation Time Factors Torsades de Pointes/*chemically induced/diagnosis/therapy
Pubmed
Création de la notice
25/01/2008 14:55
Dernière modification de la notice
03/03/2018 13:27
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