Electrophysiological localization of the subthalamic nucleus in parkinsonian patients

Détails

ID Serval
serval:BIB_07396420FAD0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Electrophysiological localization of the subthalamic nucleus in parkinsonian patients
Périodique
Neuroscience Letters
Auteur(s)
Pralong  E., Ghika  J., Temperli  P., Pollo  C., Vingerhoets  F., Villemure  J. G.
ISSN
0304-3940 (Print)
Statut éditorial
Publié
Date de publication
06/2002
Volume
325
Numéro
2
Pages
144-6
Notes
Journal Article --- Old month value: Jun 7
Résumé
Deep brain stimulation of the subthalamic nucleus (STN) is becoming the procedure of choice to reduce symptoms of Parkinson's disease such as rigidity, akinesia and tremor. We present here a series of electrophysiological recordings performed in 34 patients along a standardized electrode trajectory. Neuronal activity along the trajectory consists of a first heterogeneous population of thalamic cells with a mean frequency of 24.8+/-1.4 Hz followed by a silent zone and a second population of STN neurones with a significantly higher spiking frequency (P<0.001) of 42.3+/-1.8 Hz. This study confirms previous findings and suggests that rapid measurement of neuronal spiking frequency and burst index is sufficient to determine precisely the vertical position of the STN.
Mots-clé
Action Potentials Brain Mapping/*methods Electrophysiology Humans Neurons/physiology Parkinsonian Disorders/*physiopathology Reaction Time Subthalamic Nucleus/*physiopathology Thalamus/physiopathology
Pubmed
Web of science
Création de la notice
25/01/2008 13:49
Dernière modification de la notice
03/03/2018 13:27
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