Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum.

Détails

ID Serval
serval:BIB_072441F5ED14
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum.
Périodique
Cell
Auteur(s)
Subramanian A., Capalbo A., Iyengar N.R., Rizzo R., di Campli A., Di Martino R., Lo Monte M., Beccari A.R., Yerudkar A., Del Vecchio C., Glielmo L., Turacchio G., Pirozzi M., Kim S.G., Henklein P., Cancino J., Parashuraman S., Diviani D., Fanelli F., Sallese M., Luini A.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
07/03/2019
Peer-reviewed
Oui
Volume
176
Numéro
6
Pages
1461-1476.e23
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Maintaining the optimal performance of cell processes and organelles is the task of auto-regulatory systems. Here we describe an auto-regulatory device that helps to maintain homeostasis of the endoplasmic reticulum (ER) by adjusting the secretory flux to the cargo load. The cargo-recruiting subunit of the coatomer protein II (COPII) coat, Sec24, doubles as a sensor of folded cargo and, upon cargo binding, acts as a guanine nucleotide exchange factor to activate the signaling protein Gα12 at the ER exit sites (ERESs). This step, in turn, activates a complex signaling network that activates and coordinates the ER export machinery and attenuates proteins synthesis, thus preventing large fluctuations of folded and potentially active cargo that could be harmful to the cell or the organism. We call this mechanism AREX (autoregulation of ER export) and expect that its identification will aid our understanding of human physiology and diseases that develop from secretory dysfunction.
Mots-clé
Biological Transport, COP-Coated Vesicles/metabolism, COP-Coated Vesicles/physiology, Cell Line, Coatomer Protein/metabolism, Endoplasmic Reticulum/metabolism, Endoplasmic Reticulum/physiology, Endoplasmic Reticulum Stress/physiology, Female, GTP-Binding Protein alpha Subunits, G12-G13/metabolism, Golgi Apparatus/metabolism, Guanine Nucleotide Exchange Factors/physiology, HeLa Cells, Humans, Male, Protein Folding, Protein Transport, Proteostasis/physiology, Signal Transduction, Vesicular Transport Proteins/metabolism, AKAP, COPII, ER exit sites, ER export, PKA, auto-regulatory systems, folded cargo, homeostasis, membrane traffic, signaling
Pubmed
Web of science
Création de la notice
07/04/2019 15:17
Dernière modification de la notice
11/01/2020 6:16
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