Dietary Fiber Confers Protection against Flu by Shaping Ly6c<sup>-</sup> Patrolling Monocyte Hematopoiesis and CD8<sup>+</sup> T Cell Metabolism.

Détails

ID Serval
serval:BIB_0721FE87A408
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dietary Fiber Confers Protection against Flu by Shaping Ly6c<sup>-</sup> Patrolling Monocyte Hematopoiesis and CD8<sup>+</sup> T Cell Metabolism.
Périodique
Immunity
Auteur(s)
Trompette A., Gollwitzer E.S., Pattaroni C., Lopez-Mejia I.C., Riva E., Pernot J., Ubags N., Fajas L., Nicod L.P., Marsland B.J.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
15/05/2018
Peer-reviewed
Oui
Volume
48
Numéro
5
Pages
992-1005.e8
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fermentable dietary fiber increased survival of influenza-infected mice through two complementary mechanisms. High-fiber diet (HFD)-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6c <sup>-</sup> patrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways. Blunted CXCL1 production reduced neutrophil recruitment to the airways, thus limiting tissue immunopathology during infection. In parallel, diet-derived SCFAs boosted CD8 <sup>+</sup> T cell effector function by enhancing cellular metabolism. Hence, dietary fermentable fiber and SCFAs set an immune equilibrium, balancing innate and adaptive immunity so as to promote the resolution of influenza infection while preventing immune-associated pathology.
Mots-clé
Adaptive Immunity/drug effects, Adaptive Immunity/immunology, Animals, Antigens, Ly/immunology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Dietary Fiber/administration & dosage, Dietary Fiber/pharmacology, Fatty Acids, Volatile/immunology, Fatty Acids, Volatile/metabolism, Hematopoiesis/drug effects, Hematopoiesis/immunology, Humans, Immunity, Innate/drug effects, Immunity, Innate/immunology, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Monocytes/drug effects, Monocytes/immunology, Monocytes/metabolism, Orthomyxoviridae Infections/immunology, Protective Agents/administration & dosage, Protective Agents/pharmacology, CD8(+) T cells, SCFA, fiber, hematopoiesis, influenza, metabolism, neutrophils, patrolling monocytes
Pubmed
Web of science
Création de la notice
17/05/2018 17:34
Dernière modification de la notice
20/08/2019 13:29
Données d'usage