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Reduced pulmonary capillary blood volume as a long-term sequel of ARDS
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Journal Article --- Old month value: May
Lung function was evaluated in nine survivors of ARDS. All patients were asymptomatic at rest at the time of the study, ie, 5.5 to 19 months after extubation (mean 12.5). Six had mild to moderate exertional dyspnea. Chest x-ray films showed no gross parenchymal abnormalities. Spirometry and pulmonary mechanics were either normal or minimally altered, particularly in smokers. At submaximal exercise levels, effort was limited by tachycardia in eight patients; one subject showed ventilatory and cardiovascular limitations. It was concluded that spirometry and pulmonary mechanics are restored to normal within six months after extubation, and gas exchange abnormalities persist after ARDS and might be related to intrapulmonary shunts at rest, whereas during exercise a decreased pulmonary capillary blood volume might be the primary factor.
Adult Airway Resistance *Blood Volume Capillaries/physiopathology Exertion Female Humans Lung/*blood supply Male Middle Aged Pulmonary Circulation Pulmonary Gas Exchange *Respiration Respiratory Distress Syndrome, Adult/*physiopathology Rest Smoking Spirometry
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