Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.

Détails

ID Serval
serval:BIB_06C2A629DC6F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Périodique
Naunyn-Schmiedeberg's Archives of Pharmacology
Auteur(s)
Mennini T., Abbiati A., Caccia S., Cotecchia S., Gomez A., Garattini S.
ISSN
0028-1298 (Print)
ISSN-L
0028-1298
Statut éditorial
Publié
Date de publication
1982
Volume
321
Numéro
2
Pages
112-115
Langue
anglais
Résumé
The effect of tofizopam on 3H-flunitrazepam binding was studied in rat hippocampus and cerebellum. Tofizopam (at a concentration of 10(-7) M) increased 3H-Flu binding through a 30% rise in the Bmax with no modification of Kd in either brain area. Similar results were obtained when the binding was measured in tofizopam (50 mg/kg p.o.) pretreated rats. Even though tofizopam has no anticonvulsive action against pentetrazol-induced convulsions, it significantly potentiated the action of diazepam but with no modification of brain diazepam levels and metabolism. The brain levels of tofizopam are reported and compared to plasma levels after oral administration of 5 and 50 mg/kg to rats.
Mots-clé
Animals, Anti-Anxiety Agents, Benzodiazepines/metabolism, Brain/metabolism, Flunitrazepam/metabolism, Kinetics, Male, Membranes/metabolism, Pentylenetetrazole/metabolism, Rats, Rats, Inbred Strains, Receptors, Cell Surface/metabolism, Receptors, GABA-A, Seizures/chemically induced
Pubmed
Web of science
Création de la notice
24/01/2008 12:05
Dernière modification de la notice
03/03/2018 13:26
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