Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.

Details

Serval ID
serval:BIB_06C2A629DC6F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Journal
Naunyn-Schmiedeberg's Archives of Pharmacology
Author(s)
Mennini T., Abbiati A., Caccia S., Cotecchia S., Gomez A., Garattini S.
ISSN
0028-1298 (Print)
ISSN-L
0028-1298
Publication state
Published
Issued date
1982
Volume
321
Number
2
Pages
112-115
Language
english
Abstract
The effect of tofizopam on 3H-flunitrazepam binding was studied in rat hippocampus and cerebellum. Tofizopam (at a concentration of 10(-7) M) increased 3H-Flu binding through a 30% rise in the Bmax with no modification of Kd in either brain area. Similar results were obtained when the binding was measured in tofizopam (50 mg/kg p.o.) pretreated rats. Even though tofizopam has no anticonvulsive action against pentetrazol-induced convulsions, it significantly potentiated the action of diazepam but with no modification of brain diazepam levels and metabolism. The brain levels of tofizopam are reported and compared to plasma levels after oral administration of 5 and 50 mg/kg to rats.
Keywords
Animals, Anti-Anxiety Agents, Benzodiazepines/metabolism, Brain/metabolism, Flunitrazepam/metabolism, Kinetics, Male, Membranes/metabolism, Pentylenetetrazole/metabolism, Rats, Rats, Inbred Strains, Receptors, Cell Surface/metabolism, Receptors, GABA-A, Seizures/chemically induced
Pubmed
Web of science
Create date
24/01/2008 11:05
Last modification date
20/08/2019 12:29
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