Insulin, nitric oxide and the sympathetic nervous system: at the crossroads of metabolic and cardiovascular regulation.

Details

Serval ID
serval:BIB_06BB084A38DA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Insulin, nitric oxide and the sympathetic nervous system: at the crossroads of metabolic and cardiovascular regulation.
Journal
Journal of Hypertension
Author(s)
Sartori C., Scherrer U.
ISSN
0263-6352
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
17
Number
11
Pages
1517-1525
Language
english
Abstract
Epidemiological studies demonstrate an association between insulin resistance, hypertension and cardiovascular morbidity. Over the past decade, evidence has accumulated indicating that short-term insulin administration, in addition to its metabolic effects, also has important cardiovascular actions. The sympathetic nervous system and the L-arginine-nitric oxide pathway have emerged as central players in the mediation of insulin's cardiovascular actions. The underlying mechanisms and the factors that may govern the interaction between insulin and these two major cardiovascular regulatory systems have been studied extensively in healthy people and insulin-resistant subjects. Here we summarize the current understanding and gaps in knowledge on insulin's cardiovascular actions in humans, and discuss possible pathophysiological consequences of their alteration. Based on recent new insight, we propose that a genetic and/or acquired defect of nitric oxide synthesis could represent a central defect triggering many of the metabolic, vascular and sympathetic abnormalities characteristic of insulin-resistant states, all of which may predispose to cardiovascular disease.
Keywords
Animals, Cardiovascular Physiological Phenomena/drug effects, Humans, Insulin/pharmacology, Metabolism/drug effects, Metabolism/physiology, Nitric Oxide/physiology, Sympathetic Nervous System/physiology
Pubmed
Web of science
Create date
22/02/2008 15:02
Last modification date
20/08/2019 12:28
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