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Etude comparative du traitement de l'infection urinaire simple par une dose unique de norfloxacine versus cotrimoxazole [Comparative study of the treatment of simple urinary infection with a single dose of norfloxacin versus cotrimoxazole]
Schweizerische Medizinische Wochenschrift
Clinical Trial English Abstract Journal Article Randomized Controlled Trial --- Old month value: Jun 20
53 women with acute, uncomplicated urinary tract infection proven clinically and bacteriologically were treated, after double-blind randomisation, with a single dose of norfloxacin (1200 mg) or a single dose of cotrimoxazole (480/2400 mg). Follow-up one week after treatment showed a comparable success rate (85%) for both antibiotics. Only few minor side effects were recorded in both patient groups. Most failures were due to gram positive bacteria (coagulase-negative staphylococci). These results suggest that single dose therapy for urinary tract infections due to gram positive germs should be reconsidered.
Adolescent, Adult, Aged, Anti-Infective Agents, Urinary, Double-Blind Method, Drug Combinations, Drug Evaluation, Female, Humans, Middle Aged, Norfloxacin, Random Allocation, Sulfamethoxazole, Trimethoprim, Trimethoprim-Sulfamethoxazole Combination, Urinary Tract Infections
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