Article: article from journal or magazin.
Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty.
Computer Methods in Biomechanics and Biomedical Engineering
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Bone defects in revision knee arthroplasty are often located in load-bearing regions. The goal of this study was to determine whether a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: (1) determining the mechanical stimulus using finite element method, (2) designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, (3) identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in the scaffold and (4) estimating the stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after 3 years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5- and 2.7-fold, respectively, compared to a non-loaded situation.
Animals, Arthroplasty, Replacement, Knee, Bone and Bones/physiology, Bone and Bones/radiography, Finite Element Analysis, Models, Biological, Osteogenesis, Rats, Tissue Engineering, Tissue Scaffolds, Weight-Bearing/physiology, X-Ray Microtomography
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