Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans
Details
Serval ID
serval:BIB_065A965BDAD4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans
Journal
Journal of Clinical Investigation
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
07/1993
Volume
92
Number
1
Pages
147-54
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Euglycemic hyperinsulinemia evokes both sympathetic activation and vasodilation in skeletal muscle, but the mechanism remains unknown. To determine whether insulin per se or insulin-induced stimulation of carbohydrate metabolism is the main excitatory stimulus, we performed, in six healthy lean subjects, simultaneous microneurographic recordings of muscle sympathetic nerve activity, plethysmographic measurements of calf blood flow, and calorimetric determinations of carbohydrate oxidation rate. Measurements were made during 2 h of: (a) insulin/glucose infusion (hyperinsulinemic [6 pmol/kg per min] euglycemic clamp), (b) exogenous glucose infusion at a rate matched to that attained during protocol a, and (c) exogenous fructose infusion at the same rate as for glucose infusion in protocol b. For a comparable rise in carbohydrate oxidation, insulin/glucose infusion that resulted in twofold greater increases in plasma insulin concentrations than did glucose infusion alone, evoked twofold greater increases in both muscle sympathetic nerve activity and calf blood flow. Fructose infusion, which increased carbohydrate oxidation comparably, but had only a minor effect on insulinemia, did not stimulate either muscle sympathetic nerve activity or calf blood flow. These observations suggest that in humans hyperinsulinemia per se, rather than insulin-induced stimulation of carbohydrate metabolism, is the main mechanism that triggers both sympathetic activation and vasodilation in skeletal muscle.
Keywords
Adult
Blood Glucose/metabolism
Calorimetry
*Carbohydrate Metabolism
Catecholamines/blood
Energy Metabolism
Fructose/blood
Humans
Insulin/*blood
Muscles/*blood supply
Potassium/blood
Regional Blood Flow
Sympathetic Nervous System/*physiology
Vascular Resistance
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:36
Last modification date
20/08/2019 13:28