A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.

Détails

Ressource 1Télécharger: Cancers_2016.pdf (575.32 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_0657B56ECED9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.
Périodique
Cancers
Auteur(s)
Ahmed K., Shaw H.V., Koval A., Katanaev V.L.
ISSN-L
2072-6694
Statut éditorial
Publié
Date de publication
14/07/2016
Volume
8
Numéro
7
Pages
1-27
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers. Despite the urgent need, no WNT signaling-directed drugs currently exist, and only very few candidates have reached early phase clinical trials. Among different strategies to develop WNT-targeting anti-cancer therapies, repositioning of existing drugs previously approved for other diseases is a promising approach. Nonsteroidal anti-inflammatory drugs like aspirin, the anti-leprotic clofazimine, and the anti-trypanosomal suramin are among examples of drugs having recently revealed WNT-targeting activities. In total, 16 human-use drug compounds have been found to be working through the WNT pathway and show promise for their prospective repositioning against various cancers. Advances, hurdles, and prospects of developing these molecules as potential drugs against WNT-dependent cancers, as well as approaches for discovering new ones for repositioning, are the foci of the current review.

Pubmed
Web of science
Open Access
Oui
Création de la notice
20/12/2016 16:32
Dernière modification de la notice
20/08/2019 12:28
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