The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.

Détails

ID Serval
serval:BIB_064DBD07026C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.
Périodique
Science
Auteur(s)
Mueller C.A., Broz P., Müller S.A., Ringler P., Erne-Brand F., Sorg I., Kuhn M., Engel A., Cornelis G.R.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
310
Numéro
5748
Pages
674-676
Langue
anglais
Résumé
Many pathogenic bacteria use injectisomes to deliver effector proteins into host cells through type III secretion. Injectisomes consist of a basal body embedded in the bacterial membranes and a needle. In Yersinia, translocation of effectors requires the YopB and YopD proteins, which form a pore in the target cell membrane, and the LcrV protein, which assists the assembly of the pore. Here we report that LcrV forms a distinct structure at the tip of the needle, the tip complex. This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague.

Mots-clé
Antigens, Bacterial/physiology, Antigens, Bacterial/ultrastructure, Bacterial Outer Membrane Proteins/physiology, Bacterial Outer Membrane Proteins/ultrastructure, Genetic Complementation Test, Microscopy, Electron, Scanning, Pore Forming Cytotoxic Proteins, Yersinia enterocolitica/physiology, Yersinia enterocolitica/ultrastructure
Pubmed
Web of science
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/08/2019 13:28
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