New data and new concepts on the role of the liver in glucose homeostasis.

Details

Serval ID
serval:BIB_063719574D74
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New data and new concepts on the role of the liver in glucose homeostasis.
Journal
Current Opinion in Cinical Nutrition and Metabolic Care
Author(s)
Tappy L., Minehira K.
ISSN
1363-1950
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
4
Number
4
Pages
273-7
Language
english
Notes
Journal Article Review --- Old month value: Jul
Abstract
The liver plays a central role in the control of glucose production. It is also involved in the regulation of insulin secretion and sensitivity through neural pathways. This review will address recent developments in the mechanisms by which hepatic metabolism affects glucose homeostasis in health and disease. Oral glucose feeding elicits several systemic and hepatic alterations of intermediary metabolism through the activation of neural pathways. How this may affect glucose metabolism will be briefly discussed, and alterations of glucose homeostasis in liver disease will be briefly described. There is evidence that a portion of intrahepatic glucose can be converted into lipids in the process of de-novo lipogenesis. How this may be involved in the control of glycaemia and lipid concentrations will be reviewed. Finally, molecular mechanisms by which the alteration of liver metabolism may affect systemic glucose homeostasis will be outlined.
Keywords
Blood Glucose, Gluconeogenesis, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Liver, Liver Diseases
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 12:28
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