Inferring Orthology and Paralogy.

Détails

ID Serval
serval:BIB_062874BB14CB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inferring Orthology and Paralogy.
Périodique
Methods in molecular biology
Auteur(s)
Altenhoff A.M., Glover N.M., Dessimoz C.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
1910
Pages
149-175
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The distinction between orthologs and paralogs, genes that started diverging by speciation versus duplication, is relevant in a wide range of contexts, most notably phylogenetic tree inference and protein function annotation. In this chapter, we provide an overview of the methods used to infer orthology and paralogy. We survey both graph-based approaches (and their various grouping strategies) and tree-based approaches, which solve the more general problem of gene/species tree reconciliation. We discuss conceptual differences among the various orthology inference methods and databases and examine the difficult issue of verifying and benchmarking orthology predictions. Finally, we review typical applications of orthologous genes, groups, and reconciled trees and conclude with thoughts on future methodological developments.
Mots-clé
Orthology, Orthology benchmarking, Paralogy, Tree reconciliation
Pubmed
Open Access
Oui
Création de la notice
21/07/2019 15:39
Dernière modification de la notice
21/08/2019 5:33
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