Selection on the Major Color Gene Melanocortin-1-Receptor Shaped the Evolution of the Melanocortin System Genes.

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Version: Final published version
Serval ID
serval:BIB_05CA0CC7D793
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Selection on the Major Color Gene Melanocortin-1-Receptor Shaped the Evolution of the Melanocortin System Genes.
Journal
International journal of molecular sciences
Author(s)
Dib L., San-Jose L.M., Ducrest A.L., Salamin N., Roulin A.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
05/12/2017
Peer-reviewed
Oui
Volume
18
Number
12
Pages
NA
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Modular genetic systems and networks have complex evolutionary histories shaped by selection acting on single genes as well as on their integrated function within the network. However, uncovering molecular coevolution requires the detection of coevolving sites in sequences. Detailed knowledge of the functions of each gene in the system is also necessary to identify the selective agents driving coevolution. Using recently developed computational tools, we investigated the effect of positive selection on the coevolution of ten major genes in the melanocortin system, responsible for multiple physiological functions and human diseases. Substitutions driven by positive selection at the melanocortin-1-receptor (MC1R) induced more coevolutionary changes on the system than positive selection on other genes in the system. Contrarily, selection on the highly pleiotropic POMC gene, which orchestrates the activation of the different melanocortin receptors, had the lowest coevolutionary influence. MC1R and possibly its main function, melanin pigmentation, seems to have influenced the evolution of the melanocortin system more than functions regulated by MC2-5Rs such as energy homeostasis, glucocorticoid-dependent stress and anti-inflammatory responses. Although replication in other regulatory systems is needed, this suggests that single functional aspects of a genetic network or system can be of higher importance than others in shaping coevolution among the genes that integrate it.

Keywords
coevolution, gene evolutionary influence, melanocortin system, pleiotropy, selection
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2017 18:37
Last modification date
20/08/2019 12:27
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