Postischemic forearm skin reactive hyperemia is related to cardovascular risk factors in a healthy female population

Details

Serval ID
serval:BIB_05BE10A65979
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postischemic forearm skin reactive hyperemia is related to cardovascular risk factors in a healthy female population
Journal
Journal of Hypertension
Author(s)
Vuilleumier  P., Decosterd  D., Maillard  M., Burnier  M., Hayoz  D.
ISSN
0263-6352 (Print)
Publication state
Published
Issued date
09/2002
Volume
20
Number
9
Pages
1753-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
OBJECTIVE: To examine whether forearm postischemic skin reactive hyperemia (SRH) measured by laser Doppler flowmetry (LDF) can be used to explore microvascular function and whether LDF response is related to cardiovascular (CV) risk in a population study. METHODS: SRH of the forearm defined as the percentage increase in cutaneous blood flow from resting conditions to peak dilation following a 2 min upper arm occlusion and CV risk factors were measured prospectively in 862 healthy females screened for cardiovascular risk factors in the context of a campaign designed to promote the 'control' of CV risk factors in women. RESULTS: The Framingham risk score was constructed from age, sex, systolic and diastolic blood pressure, diabetes, total and high-density lipoprotein-cholesterol and left ventricular hypertrophy (Cornell product. The Cornell product for women was calculated as the QRS duration (ms) (R aVL + S V3 + 6 mV)). Although the score was low in this female population (CV event risk at 10 years 7.89) (95% confidence interval, 7.49-8.30) aged 40 to 75 years, we observed an inverse correlation between SRH of the forearm and the CV risk score ( P<0.001). Hormonal replacement therapy (39.4% of the study population was on hormone replacement therapy) had no significant influence on forearm postischemic SRH in this particular population. CONCLUSIONS: This study shows that in a very low CV risk female population, a significant correlation can be observed between the weight of CV risks and the impairment of postischemic forearm SRH. Thus, skin laser Doppler flowmetry may represent a valuable, simple and non-invasive tool to assess and monitor microvascular function in future prospective observational and interventional studies.
Keywords
Adult Aged Cardiovascular Diseases/*etiology Female Forearm/*blood supply Humans Hyperemia/*etiology/ultrasonography Ischemia/*complications Laser-Doppler Flowmetry Middle Aged Reference Values Risk Factors Skin/*blood supply
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 12:27
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