Article: article from journal or magazin.
Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity.
Publication types: ARTICLEPublication Status: epublishDocument Type: Editorial Material
Glycolytic activity in T cells governs T cell responses by controlling various cellular processes, including proliferation, survival, and effector functions. We recently showed that the tumor microenvironment diminishes T cell antitumor responses by depriving glucose to infiltrating T cells. Moreover, metabolic rewiring tumor-reactive T cells sustain T cell metabolic fitness and antitumor responses.
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