Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.

Détails

ID Serval
serval:BIB_05357332B60D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.
Périodique
The Journal of investigative dermatology
Auteur(s)
Sardella C., Winkler C., Quignodon L., Hardman J.A., Toffoli B., Giordano Attianese GMP, Hundt J.E., Michalik L., Vinson C.R., Paus R., Desvergne B., Gilardi F.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
138
Numéro
3
Pages
500-510
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
PPARγ regulates multiple aspects of skin physiology, including sebocyte differentiation, keratinocyte proliferation, epithelial stem cell survival, adipocyte biology, and inflammatory skin responses. However, the effects of its global deletion, namely of nonredundant key functions of PPARγ signaling in mammalian skin, are yet unknown because of embryonic lethality. Here, we describe the skin and hair phenotype of a whole-body PPARγ-null mouse (Pparg <sup>Δ/Δ</sup> ), obtained by preserving PPARγ expression in the placenta. Pparg <sup>Δ/Δ</sup> mice exhibited total lipoatrophy and complete absence of sebaceous glands. Right after birth, hair follicle (HF) morphogenesis was transiently delayed, along with reduced expression of HF differentiation markers and of transcriptional regulators necessary for HF development. Later, adult Pparg <sup>Δ/Δ</sup> mice developed scarring alopecia and severe perifollicular inflammation. Skin analyses in other models of lipodystrophy, AZIP <sup>tg/+</sup> and Adipoq-Cre <sup>tg/+</sup> Pparg <sup>fl/fl</sup> mice, coupled with skin graft experiments, showed that the early defects observed in hair morphogenesis were caused by the absence of adipose tissue. In contrast, the late alteration of HF cycle and appearance of inflammation were observed only in Pparg <sup>Δ/Δ</sup> mice and likely were due to the lack sebaceous glands. Our findings underscore the increasing appreciation for the importance of adipose tissue-mediated signals in HF development and function.
Mots-clé
Animals, Cell Differentiation, Disease Models, Animal, Hair Follicle/growth & development, Homeostasis, Lipodystrophy/pathology, Mice, Mice, Knockout, Morphogenesis, PPAR gamma/genetics, PPAR gamma/physiology
Pubmed
Web of science
Création de la notice
09/10/2017 15:16
Dernière modification de la notice
20/08/2019 12:27
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