Article: article from journal or magazin.
Soft tissue sarcomas with complex genomic profiles.
Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed.
Soft tissue Sarcoma, Karyotype, Genetics, Nerve Sheath Tumors, Malignant Fibrous Histiocytoma, Myxoinflammatory Fibroblastic Sarcoma, Dna Copy Number, Smooth-Muscle Tumors, Champ Study-Group, Mesenchymal Progenitor Cells, Gene-Expression Analysis, Of-The-Literature, Pleomorphic Liposarcoma
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