Endophthalmitis following intravitreal injections.

Details

Serval ID
serval:BIB_04B8E2F9681A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Endophthalmitis following intravitreal injections.
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Author(s)
Irigoyen C., Ziahosseini K., Morphis G., Stappler T., Heimann H.
ISSN
1435-702X (Electronic)
ISSN-L
0721-832X
Publication state
Published
Issued date
04/2012
Peer-reviewed
Oui
Volume
250
Number
4
Pages
499-505
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To report the clinical features, culture results, management and visual outcome of patients with endophthalmitis following intravitreal injections.
Retrospective review of all patients with suspected endophthalmitis after intravitreal injections treated with intravitreal antibiotics (teicoplanin and ciprofloxacin) at a referral centre between January 2003 and December 2010.
Nineteen cases that had aqueous or vitreous biopsy were identified. Nine had negative culture. Ten had positive culture; Staphylococcus species in 4/10, Streptococcus species in 4/10, E. coli in 1/10 and gram-negative bacilli in 1/10. Symptoms developed within the first 48 hours in all. One of ten culture-positive cases had no pain on presentation, while 5/9 patients with negative culture reported pain. Initial treatment consisted of intravitreal antibiotics in all cases, 6/19 cases required a second intravitreal antibiotic injection, 4/19 underwent vitrectomy as secondary therapy. At the last follow up, 7/19 patients had visual acuity of 6/18 or better, 9/19 had visual acuity of 6/60 or worse.
The overall numbers of patients with endophthalmitis following intravitreal injections has risen dramatically over the past years. In contrast to earlier reports of multicentre studies, outcome of patients is relatively poor in the current treatment settings. We did not find clinical features useful in identifying cases with negative culture.
Keywords
Aged, Aged, 80 and over, Angiogenesis Inhibitors/administration & dosage, Anti-Bacterial Agents/therapeutic use, Aqueous Humor/microbiology, Bacteria/isolation & purification, Ciprofloxacin/therapeutic use, Combined Modality Therapy, Endophthalmitis/diagnosis, Endophthalmitis/microbiology, Endophthalmitis/therapy, Eye Infections, Bacterial/diagnosis, Eye Infections, Bacterial/microbiology, Eye Infections, Bacterial/therapy, Female, Humans, Intravitreal Injections/adverse effects, Male, Middle Aged, Retrospective Studies, Teicoplanin/therapeutic use, Treatment Outcome, Triamcinolone Acetonide/administration & dosage, Vascular Endothelial Growth Factor A/antagonists & inhibitors, Visual Acuity/physiology, Vitrectomy, Vitreous Body/microbiology
Pubmed
Web of science
Create date
30/08/2018 14:43
Last modification date
20/08/2019 12:26
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