HCV infection after liver transplantation is associated with lower levels of alloreactive CD4+CD25+CD45RO+IL-7R+high+ T cells

Détails

ID Serval
serval:BIB_04AB1F93A528
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
HCV infection after liver transplantation is associated with lower levels of alloreactive CD4+CD25+CD45RO+IL-7R+high+ T cells
Titre de la conférence
8th American Transplant Congress
Auteur(s)
Ciuffreda Donatella, Codarri Laura, Buhler Leo, Giostra Emiliano, Mentha Gilles, Pantaleo Giuseppe, Pascual Manuel
Adresse
Toronto, Canada, May 31-June 4, 2008
ISBN
1600-6135
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
8
Série
American Journal of Transplantation
Pages
389
Langue
anglais
Notes
Publication type : Meeting Abstract
Résumé
Aim:
Expression of IL-7R discriminates alloreactive CD4 T cells (Foxp3 negative), from
IL-7Rlow regulatory CD4 T cells (Foxp3 positive). Chronic hepatitis C virus infection
(HCV) reduces expression of IL-7R on T cells thus promoting persistence of infection.
The aim of this study was to analyze the effect of HCV infection on the expression of
IL-7R of activated CD4+ T cells in liver transplant patients.
Patients and methods:
We analyzed PBMC from liver transplant recipients for the expression of CD4, CD25,
FoxP3, IL-7R (24 HCV negative and 29 HCV-chronically infected). We compared
these data with non-transplanted individuals (52 HCV-chronically infected patients
and 38 healthy donors).
Results:
In HCV-infected liver transplant recipients, levels of CD4+CD25+CD45RO+IL-7R+
T cells were significantly reduced (10.5+/-0.9%) when compared to non-HCV-infected
liver transplant recipients (17.6+/-1.4%) (P<0.001), while both groups (HCV-infected
and negative transplant recipients) had significantly higher levels than healthy
individuals (6.6+/-0.9%) (P<0.0001). After successful antiviral therapy (sustained
antiviral response), 6 HCV-infected transplant recipients showed an increase of
CD4+CD25+CD45RO+IL-7R+ T cells, reaching levels similar to that of non-HCVinfected
recipients (10.73+/-2.63% prior therapy versus 21.7+/-6.3% after clearance
of HCV). (P<0.05) In 4 non-responders (i.e. HCVRNA remaining present in serum),
levels of CD4+CD25+CD45RO+IL-7R+ T cells remained unmodified during and after
antiviral treatment (11.8+/- 3.3% versus 11.3+/-3.3% respectively).
Conclusions:
Overall, these data indicate that CD4+CD25+CD45RO+IL-7R+ T cells appear to be
modulated by chronic HCV infection after liver transplantation.
Whether lower levels of alloreactive T cells in HCV-infected liver transplant recipients
are associated with a tolerogenic profile remains to be studied.
Mots-clé
,
Web of science
Création de la notice
28/12/2010 14:36
Dernière modification de la notice
20/08/2019 12:26
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