Fatal intravenous injection of potassium: Is postmortem biochemistry useful for the diagnosis?

Détails

ID Serval
serval:BIB_049FF86FFD8A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Fatal intravenous injection of potassium: Is postmortem biochemistry useful for the diagnosis?
Périodique
Forensic science international
Auteur(s)
Palmiere C., Scarpelli M.P., Varlet V., Baumann P., Michaud K., Augsburger M.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Statut éditorial
Publié
Date de publication
05/2017
Peer-reviewed
Oui
Volume
274
Pages
27-32
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Fatal cases of potassium overdoses have traditionally been considered indemonstrable due postmortem biochemical investigation limits (mainly potassium determination in postmortem serum and vitreous humor). Nevertheless, some authors have expressed a divergent opinion over the years based on the results of their own investigations. In this study, we investigated left vitreous, right vitreous, postmortem serum from peripheral blood, postmortem serum from cardiac blood, urine, pericardial and cerebrospinal fluid potassium concentrations in 21 forensic autopsy cases. One of these was a case of accidental, fatal intravenous potassium injection in a hospitalized patient. The other twenty cases were subjects with various causes of death unrelated to potassium administration and comparable postmortem intervals. Our aim was to assess whether postmortem biochemical investigations performed in several biological samples may be useful in diagnosing exogenous potassium administration. No statistically significant differences were observed between the measured concentrations in the fatal case of potassium intravenous administration and the control cases in any of the tested samples. Potassium concentrations in the investigated case of exogenous potassium injection were within the range of those measured in the control cases, irrespective of the tested biological sample. Our findings corroborate the conclusions of former authors who highlighted that circumstantial evidence provides the greatest diagnostic contribution in situations of suspected potassium poisoning. This is due to the objective limitations demonstrated by postmortem biochemical investigations in such cases, even when potassium measurements are carried out in several biological samples of satisfying quality and within a relatively short postmortem interval.
Mots-clé
Adult, Aged, Case-Control Studies, Female, Humans, Injections, Intravenous, Male, Medication Errors, Middle Aged, Pericardial Fluid/chemistry, Poisoning/diagnosis, Potassium/analysis, Potassium/poisoning, Vitreous Body/chemistry, Young Adult, Autopsy, Poisoning, Postmortem biochemistry, Potassium, Vitreous humor
Pubmed
Web of science
Création de la notice
13/12/2016 8:48
Dernière modification de la notice
20/08/2019 12:26
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