New developments in external beam radiotherapy for retinoblastoma: from lens to normal tissue-sparing techniques.

Détails

ID Serval
serval:BIB_048F673AE2AE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
New developments in external beam radiotherapy for retinoblastoma: from lens to normal tissue-sparing techniques.
Périodique
Clinical and Experimental Ophthalmology
Auteur(s)
Munier F.L., Verwey J., Pica A., Balmer A., Zografos L., Abouzeid H., Timmerman B., Goitein G., Moeckli R.
ISSN
1442-9071 (Electronic)
ISSN-L
1442-6404
Statut éditorial
Publié
Date de publication
2008
Volume
36
Numéro
1
Pages
78-89
Langue
anglais
Notes
Publication types: Case Reports ; Historical Article ; Journal Article ; Review
Résumé
Historically, retinoblastoma was treated with external beam radiotherapy (EBR) and for many years this was the accepted standard of care. With greater knowledge of radiation-induced morbidity and mortality, the trend over the past decade has shifted towards primary chemotherapy for most globe conservative treatments. Such a radical change in treatment modalities has restrained EBR to second-line and salvage indications with little consensus regarding dose, timing and techniques. New radiotherapy options now allow for more focused radiation to the globe with further sparing of adjacent structures in such a way that their role in the management of retinoblastoma need to be reappraised. In this perspective paper, first the historical techniques of using EBR primarily with linear accelerated photons are reviewed. Then modern approaches are described, such as stereotactic conformal radiotherapy using a micromultileaf collimator, and proton therapy using a fixed horizontal beam and tantalum localization, or a rotating ganthry with spot scanning. For the first time, to the authors' knowledge, the benefits of these new irradiation modalities over conventional EBR are illustrated with six successfully treated pilot cases. Finally, some guidelines are provided regarding indications to modern radiation therapy in patients requiring second-line or salvage treatment for intraocular retinoblastoma, as well as adjuvant therapy for orbital involvement.
Mots-clé
Child, Preschool, Female, History, 20th Century, Humans, Infant, Male, Particle Accelerators, Photons/therapeutic use, Radiotherapy/history, Radiotherapy/methods, Radiotherapy, Adjuvant, Radiotherapy, Conformal, Retinal Neoplasms/radiotherapy, Retinoblastoma/radiotherapy, Salvage Therapy, Stereotaxic Techniques
Pubmed
Web of science
Création de la notice
28/04/2008 10:35
Dernière modification de la notice
20/08/2019 12:26
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