Differential effect of long versus short wavelength light exposure on pupillary re-dilation in patients with outer retinal disease.

Détails

ID Serval
serval:BIB_045F366C0B96
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential effect of long versus short wavelength light exposure on pupillary re-dilation in patients with outer retinal disease.
Périodique
Clinical and Experimental Ophthalmology
Auteur(s)
Léon L., Crippa S.V., Borruat F.X., Kawasaki A.
ISSN
1442-9071 (Electronic)
ISSN-L
1442-6404
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
40
Numéro
1
Pages
e16-e24
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
BACKGROUND: In patients with outer retinal degeneration, a differential pupil response to long wavelength (red) versus short wavelength (blue) light stimulation has been previously observed. The goal of this study was to quantify differences in the pupillary re-dilation following exposure to red versus blue light in patients with outer retinal disease and compare them with patients with optic neuropathy and with healthy subjects.
DESIGN: Prospective comparative cohort study.
PARTICIPANTS: Twenty-three patients with outer retinal disease, 13 patients with optic neuropathy and 14 normal subjects.
METHODS: Subjects were tested using continuous red and blue light stimulation at three intensities (1, 10 and 100 cd/m2) for 13 s per intensity. Pupillary re-dilation dynamics following the brightest intensity was analysed and compared between the three groups.
MAIN OUTCOME MEASURES: The parameters of pupil re-dilation used in this study were: time to recover 90% of baseline size; mean pupil size at early and late phases of re-dilation; and differential re-dilation time for blue versus red light.
RESULTS: Patients with outer retinal disease showed a pupil that tended to stay smaller after light termination and thus had a longer time to recovery. The differential re-dilation time was significantly greater in patients with outer retinal disease (median = 28.0 s, P < 0.0001) compared with controls and patients with optic neuropathy.
CONCLUSIONS: A differential response of pupil re-dilation following red versus blue light stimulation is present in patients with outer retinal disease but is not found in normal eyes or among patients with visual loss from optic neuropathy.
Mots-clé
Adolescent, Adult, Aged, Child, Female, Humans, Light, Male, Middle Aged, Optic Nerve Diseases/physiopathology, Photic Stimulation, Prospective Studies, Pupil/radiation effects, Reflex, Pupillary/physiology, Retinal Degeneration/physiopathology, Visual Field Tests, Visual Fields/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/12/2011 10:27
Dernière modification de la notice
20/08/2019 12:26
Données d'usage