Parkinsonian-Pyramidal syndromes: A systematic review.

Détails

ID Serval
serval:BIB_04567B6293BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Parkinsonian-Pyramidal syndromes: A systematic review.
Périodique
Parkinsonism & related disorders
Auteur(s)
Tranchant C., Koob M., Anheim M.
ISSN
1873-5126 (Electronic)
ISSN-L
1353-8020
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
39
Pages
4-16
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Parkinsonian-Pyramidal syndrome (PPS), defined as the combination of both pyramidal and parkinsonian signs is a concept that recently emerged. PPS may manifest itself in numerous neurodegenerative diseases, many of these being inherited. Their diagnosis is a major challenge for the clinical management, for the prognosis, for genetic counselling and, in a few cases, which should not be neglected, for specific treatment.
Our objective is to provide a review of PPS and an algorithm in order to guide their diagnosis in clinical practice.
We performed an exhaustive PubMed and OMIM research matching the following key words: "Parkinsonism and pyramidal signs" or "Parkinsonism and spasticity" or "pallido-pyramidal syndrome" or "Parkinsonism and spastic paraplegia". English publications from the last ten years were included.
We propose a pragmatic presentation based on several established classifications and we will distinguish inherited PPS found in complex hereditary spastic paraplegia, young onset parkinsonism, neurodegeneration with brain iron accumulation, primary familial brain calcifications, inborn errors of metabolism, and few rare others inherited neurodegenerative diseases, then non-inherited neurodegenerative PPS. We therefore suggest guidelines (based on age at onset, family history, associated clinical signs, brain MRI findings as well as certain laboratory investigations), for the diagnosis and the management of PPS. Many pathophysiological pathways may underlie PPS but the most frequent are those usually involved in both inherited Parkinson's disease and spastic paraplegia, i.e. mitochondrial pathway, vesicular trafficking including endosomal and lysosomal pathways as well as autophagy.

Mots-clé
Juvenile parkinsonism, NBIA, Parkinsonism, Pyramidal signs, Spasticity
Pubmed
Web of science
Création de la notice
28/08/2017 15:15
Dernière modification de la notice
03/03/2018 13:22
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