Rapid evolution of cancer/testis genes on the X chromosome.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_04291E573A9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Rapid evolution of cancer/testis genes on the X chromosome.
Périodique
BMC Genomics
Auteur(s)
Stevenson B.J., Iseli C., Panji S., Zahn-Zabal M., Hide W., Old L.J., Simpson A.J., Jongeneel C.V.
ISSN
1471-2164
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
8
Pages
129
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
BACKGROUND: Cancer/testis (CT) genes are normally expressed only in germ cells, but can be activated in the cancer state. This unusual property, together with the finding that many CT proteins elicit an antigenic response in cancer patients, has established a role for this class of genes as targets in immunotherapy regimes. Many families of CT genes have been identified in the human genome, but their biological function for the most part remains unclear. While it has been shown that some CT genes are under diversifying selection, this question has not been addressed before for the class as a whole. RESULTS: To shed more light on this interesting group of genes, we exploited the generation of a draft chimpanzee (Pan troglodytes) genomic sequence to examine CT genes in an organism that is closely related to human, and generated a high-quality, manually curated set of human:chimpanzee CT gene alignments. We find that the chimpanzee genome contains homologues to most of the human CT families, and that the genes are located on the same chromosome and at a similar copy number to those in human. Comparison of putative human:chimpanzee orthologues indicates that CT genes located on chromosome X are diverging faster and are undergoing stronger diversifying selection than those on the autosomes or than a set of control genes on either chromosome X or autosomes. CONCLUSION: Given their high level of diversifying selection, we suggest that CT genes are primarily responsible for the observed rapid evolution of protein-coding genes on the X chromosome.
Mots-clé
Animals, Chromosomes, Human, X, Evolution, Molecular, Expressed Sequence Tags, Female, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Genome, Human, Humans, Immunotherapy, Male, Pan troglodytes, Polymerase Chain Reaction, Sequence Alignment, Testis
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:39
Dernière modification de la notice
08/05/2019 13:51
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